Casa
rva ao vivo

Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4

Por um escritor misterioso

Descrição
The objective of the study was to compare relative uptake, metabolism, and β-receptor affinity of the new positron-emitting uptake-1 tracer (1 R ,2 S )-4-18F-fluorometaraminol (4-FM) with those of the SPECT pharmaceutical meta-123I-iodobenzylguanidine (MIBG) in Wistar Kyoto (WKY) rats and spontaneously hypertensive (SHR) rats. Methods: No-carrier-added 4-18F-FM was applied to SHR and WKY rats in vivo and to retrogradely perfused hearts in vitro. Cardiac and extracardiac distribution was assessed, and metabolite formation was determined by thin-layer chromatography. The in vivo experiments were repeated with no-carrier-added 123I-MIBG. By means of autoradiography, the β-receptor affinity of 4-FM was compared with that of MIBG and propranolol (10 μmol/L) through displacement of 125I-iodocyanopindolol (1.5 pmol/L) in slices of heart and spleen. Results: Cardiomyopathic hearts showed heterogeneous 4-18F-FM uptake with gradients up to 3.6 in vivo and in vitro between different regions of the heart. Control hearts showed such gradients in 4-18F-FM uptake only in vitro. 123I-MIBG exhibited a less heterogeneous in vivo distribution in SHR hearts. Extracardiac differences between WKY and SHR were found for uptake of 4-18F-FM in the spleen (63.3% ± 4% vs. 38.8% ± 5.7% of cardiac activity) and for renal uptake of 123I-MIBG (373% ± 27% vs. 81.4% ± 17% of cardiac activity). Metabolites of 4-18F-FM were found only in the liver and those of 123I-MIBG were found in the liver and kidney with a nearly equal relative fraction in both types of animals of about 20%, 60%, and 30%, respectively. 4-FM suppressed cardiac-specific β-receptor binding of 125I-iodocyanopindolol in heart and spleen of both types of animals significantly, whereas MIBG had almost no effect. Conclusion: The more heterogeneous cardiac distribution of 4-18F-FM suggests that it reflects alterations in uptake-1 better than 123I-MIBG in addition to the possibility of quantification and higher spatial resolution by PET compared with SPECT. Altered biotransformation in cardiomyopathic diseases may also impair the evaluation of 123I-MIBG-SPECT data. The β-receptor binding of 4-18F-FM must be further elucidated.
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Minimal Out-of-Equilibrium Metabolism for Synthetic Cells: A Membrane Perspective
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Frontiers Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Biomedicines, Free Full-Text
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4-18F-Fluorometaraminol and 123I-MIBG in Normotensive and Spontaneously Hypertensive Rats
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
MAVS integrates glucose metabolism and RIG-I-like receptor signaling
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness? - Hostrup - 2022 - The Journal of Physiology - Wiley Online Library
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
NF-κB: blending metabolism, immunity, and inflammation: Trends in Immunology
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Lipogenesis inhibitors: therapeutic opportunities and challenges
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance - ScienceDirect
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Frontiers Akt: A Potential Drug Target for Metabolic Syndrome
Relative Uptake, Metabolism, and β-Receptor Binding of (1R,2S)-4
Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism
de por adulto (o preço varia de acordo com o tamanho do grupo)