Viruses, Free Full-Text

Por um escritor misterioso

Descrição

Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. However, little is known about its roles in regulation of the immune system. In the current study, we observed that expression of NAC1 impacted the survival of CD8+ T cells in vitro. NAC1−/− CD8+ T cells displayed lower metabolism, including reduced glycolysis and oxidative phosphorylation. In vivo, compared with wild-type (WT) mice, NAC1−/− mice produced a lower response to vaccinia virus (VACV) infection, and viral antigen (Ag)-specific CD8+ T cells decreased more slowly. Additionally, we observed that the NAC1−/− mice demonstrated a stronger memory formation of viral Ag-specific CD8+ T cells post-viral infection. Mechanically, we identified that compared with WT CD8+ T cells, the Interferon Regulatory Factor 4 (IRF4), a key transcription factor in T cell development, was highly expressed in NAC1−/− CD8+ T cells, insinuating that IRF4 could be a critical regulatory target of NAC1 in the memory formation of CD8+ T cells. Our results indicate that NAC1 restrains the memory formation of CD8+ T cells by modulating IRF4, and targeting NAC1 may be exploited as a new approach to boosting CD8+ T cell memory.
Viruses, Free Full-Text
Avira Free Antivirus for Windows free download
Viruses, Free Full-Text
66,493 Virus Structure Images, Stock Photos, 3D objects, & Vectors
Viruses, Free Full-Text
The ABCs of Malware A Small-Business Owner's Guide to
Viruses, Free Full-Text
Remove Viruses Detected (5) Pop-up Scam [Virus Removal]
Viruses, Free Full-Text
Free Virus Scanner 2023, Online Virus Scan
Viruses, Free Full-Text
Difference between Virus and Virion
Viruses, Free Full-Text
Infectious virus in exhaled breath of symptomatic seasonal
Viruses, Free Full-Text
Cartoon viruses. Germs virus character, funny bacteria types
Viruses, Free Full-Text
Downloading Virus Trojan_horse.exe POP-UP Scam - Removal and
Viruses, Free Full-Text
Hp Vca 7.4 Download - Colaboratory
Viruses, Free Full-Text
Pandemic origins and a One Health approach to preparedness and
Viruses, Free Full-Text
What Is a Computer Virus?, Computer Virus Definition
Viruses, Free Full-Text
Virus Structure, Anatomy & Function - Video & Lesson Transcript
Viruses, Free Full-Text
Viruses, Free Full-Text
Viruses, Free Full-Text
Monkeypox Virus Infection in Humans across 16 Countries — April
de por adulto (o preço varia de acordo com o tamanho do grupo)