GPC2-CAR T cells tuned for low antigen density mediate potent
Por um escritor misterioso
Descrição
Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…
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Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://www.researchgate.net/publication/353667754/figure/fig1/AS:1052757087752193@1628008257909/D3-GPC2-PBD-is-potently-cytotoxic-to-GPC2-expressing-SCLCs-A-Quantification-of.png)
D3-GPC2-PBD is potently cytotoxic to GPC2-expressing SCLCs (A)
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://www.frontiersin.org/files/Articles/846346/fimmu-13-846346-HTML/image_m/fimmu-13-846346-g001.jpg)
Frontiers Adoptive Cell Therapy in Pediatric and Young Adult Solid Tumors: Current Status and Future Directions
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://www.frontiersin.org/files/Articles/1321596/fimmu-14-1321596-HTML/image_m/fimmu-14-1321596-g002.jpg)
Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://ars.els-cdn.com/content/image/1-s2.0-S2666379121001300-gr7.jpg)
CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://www.astctjournal.org/cms/attachment/719261ae-31b8-4b05-b3a3-feba082cd05a/gr2_lrg.jpg)
Mechanisms of Resistance and Treatment of Relapse after CAR T-cell Therapy for Large B-cell Lymphoma and Multiple Myeloma - Transplantation and Cellular Therapy, Official Publication of the American Society for Transplantation and
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://www.researchgate.net/publication/367065322/figure/fig4/AS:11431281112755767@1673529609948/Head-to-head-comparison-of-the-GPC2-CAR-CT328HBBz-versus-a-GD2-CAR-K66628HBBz_Q320.jpg)
PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2023/nejm_2023.388.issue-14/nejmoa2210859/20230403/images/img_medium/nejmoa2210859_f0.jpeg)
GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://www.frontiersin.org/files/Articles/1321596/fimmu-14-1321596-HTML/image_m/fimmu-14-1321596-g003.jpg)
Frontiers Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://jitc.bmj.com/content/jitc/11/1/e005881/F2.large.jpg)
Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://article.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809206/2768-6698-28-9-206/fig2.jpg)
Present Status and Advances in Chimeric Antigen Receptor T Cell Therapy for Glioblastoma
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://ars.els-cdn.com/content/image/1-s2.0-S1535610821006589-gr1.jpg)
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect
![GPC2-CAR T cells tuned for low antigen density mediate potent](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs11912-023-01380-x/MediaObjects/11912_2023_1380_Fig1_HTML.png)
CAR-T Therapies in Solid Tumors: Opportunities and Challenges
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CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research
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