JCM, Free Full-Text
Por um escritor misterioso
Descrição
Non-syndromic tooth agenesis (ns-TA) is one of the most common dental anomalies characterized by the congenital absence of at least one permanent tooth (excluding third molars). Regarding the essential role of genetic factors in ns-TA aetiology, the present study aimed to identify novel pathogenic variants underlying hypodontia and oligodontia. In a group of 65 ns-TA patients and 127 healthy individuals from the genetically homogenous Polish population, the coding sequences of 423 candidate genes were screened using targeted next-generation sequencing. Pathogenic and likely pathogenic variants were identified in 37 (56.92%) patients, including eight nucleotide alternations of genes not previously implicated in ns-TA (CHD7, CREBBP, EVC, LEF1, ROR2, TBX22 and TP63). However, since only single variants were detected, future research is required to confirm and fully understand their role in the aetiology of ns-TA. Additionally, our results support the importance of already known ns-TA candidate genes (AXIN2, EDA, EDAR, IRF6, LAMA3, LRP6, MSX1, PAX9 and WNT10A) and provide additional evidence that ns-TA might be an oligogenic condition involving the cumulative effect of rare variants in two or more distinct genes.
JCM, Free Full-Text
How Often Should Quantiferon Gold Test Be Done - Printable Templates Free
JCM, Free Full-Text
Diseases of the skin: their constitutional nature and cure : Burnett, J. Compton (James Compton), 1840-1901? : Free Download, Borrow, and Streaming : Internet Archive
Marshall JCM 800 Full Stack by maggiemgill on DeviantArt
Premium Vector Take heart i have overcome the world john 1633
Central service technical manual : Free Download, Borrow, and Streaming : Internet Archive
JCM Resources A Mineral Rights Acquisitions Company
JCAMP-DX format mass spectrum file for 2 chlorophenol
Ucr Spss Get File - Colaboratory
de
por adulto (o preço varia de acordo com o tamanho do grupo)
